Hernia in the kooikerhondje

Do you own a kooikerhondje with a herniated disc (IVDD) diagnosis? Have you had your dog genotyped or are you open to do so? If your dog has been diagnosed with Intervertebral disc disease, or herniated disc through an x-ray, neurological exam, MRI or CT scan you may be able to help us prevent the spread of this disease in the breed.

As part of her PhD project, veterinary geneticist Citlalli Limpens is currently studying the genetic background of this disease in the kooikerhondje. Within this project, we aim to investigate whether mutation in the FGF4 gene is related to IVDD in the kooikerhondje breed.

For this study, we are looking for pedigree kooikerhondjes diagnosed with IVDD by a veterinarian.
If your dog is eligible, and you are interested in participating, please contact us at: c.limpens@uu.nl or ecgg@uu.nl.

About the study

If your dog meets the above requirements, a veterinary specialist will review their veterinary records to verify the IVDD diagnosis. Once your dog is confirmed to meet the study’s criteria, we would like to receive a blood sample from your dog. If DNA of your dog was previously stored at Utrecht University (when the dog was sent in for ENM or VWD diagnosis), you only have to give us consent to use this data for the study. If your dog was also genotyped using a commercial kit, such as Embark, you can additionally share this data with us, by filling in the following survey:

https://survey.uu.nl/jfe/form/SV_6QfbBVADCYQhaQK

During this study, your dog’s pedigree and genotype data will be analyzed and compared to a group of kooikerhondjes that did not develop IVDD. This will help us with future breeding advice with regard to IVDD in the kooikerhondje.

As part of this study, you will receive a report with the relevant genetic information from the population. You will also be informed on the final results of the study.

About IVDD

Intervertebral Disc Disease is a degenerative disease that affects the dog’s intervertebral discs. When herniation of the intervertebral disc takes place, this will compress the spinal cord, causing the clinical signs: pain and mobility issues, keeping the neck low and inability to lift the head, neck or back pain, weak, abnormal or uncoordinated limb movement, incontinence, shivering, paralysis, and hunched back. The clinical signs can vary depending on the area of the neck or back the herniation takes place.
This disease can be diagnosed via an X-ray, CT scan, MRI and neurological exam.

If you are interested in participating in this study, please send over all clinical data you have available of your dog (including clinical images).

A donation of € 10.000,-

The Deutsche Club für Kooikerhondje e.V. (DCK) has made a donation of € 10,000.00 available for research into polymyositis. The story behind it (in German) can be found on this website: Bereitstellung von forschungsmitteln. Because of many years of good cooperation between the various sister associations, there was such a great faith that the DCK chairman, my colleague Mr Roll, asked the VHNK for the most efficient way to donate the money. In consultation with Dr. Mandigers, the DCK, the VHNK and a lawyer devised a construction to avoid having to pay overhead costs.

The money has now been deposited into a third-party funds account and is used from there to pay for research. Management of the account is in the hands of the VHNK. In this way the entire amount can be used for research. Costs of the bank account and the administration are settled by the VHNK. We are kept informed of the expenditure four times a year by means of a report by dr. P. Mandigers.

We are very happy and grateful for the DCK initiative. One thing is certain: € 10,000.00 will help, but it is not nearly enough. Therefore, this writing is a call to donate money for research into polymyositis.

The third-party funds account will remain open for gifts from others for the time being.

BIC: RABO NL2U
IBAN NL70 RABO 0328 3693 06
begunstigde / recipient / Empfänger: Vereniging Het Nederlandse Kooikerhondje

For information you can contact the treasurer or the chairman of the VHNK.


A note from the chairman of the DCK: Bereitstellung von Forschungsmitteln

Word of thanks from Paul Mandigers: Dankwoord NL/EN/DE